What does hepatocyte growth factor do?

Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration.

Where is hepatocyte growth factor produced?

stromal cells
HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its receptor, c-Met.

Is hepatocyte growth factor a cytokine?

Hepatocyte growth factor (HGF), otherwise known as scatter factor (SF), is a recently identified cytokine which exerts a wide spectrum of biological functions on a variety of cell types. Its receptor is encoded by the c-met proto-oncogene.

Is hepatocyte growth factor a protein?

MET Ligand HGF/SF was isolated concurrently as a liver mitogen (hepatocyte growth factor) and as a motility factor for epithelial cells (scatter factor). HGF/SF is a protein of 728 amino acids that differs from other polypeptide growth factors and is closely related to the proenzyme plasminogen.

Is hepatocyte growth factor safe?

Increase in ankle pressure index more than 0.1 was observed in 5 of 5 patients. The long diameter of 8 of 11 ischemic ulcers in 4 patients was reduced >25%. Intramuscular injection of naked HGF plasmid is safe, feasible, and can achieve successful improvement of ischemic limbs.

What is unique about hepatocytes?

Hepatocytes are the chief functional cells of the liver and perform an astonishing number of metabolic, endocrine and secretory functions. Roughly 80% of the mass of the liver is contributed by hepatocytes. In three dimensions, hepatocytes are arranged in plates that anastomose with one another.

Do hepatocytes produce digestive enzymes?

Answer and Explanation: (a) Digestive enzymes are produced by cells such as acinar cells of the pancreas. Hepatocytes do not produce these.

What is difference between interleukin and cytokine?

Interleukins are a subset of a larger group of cellular messenger molecules called cytokines, which are modulators of cellular behaviour. Like other cytokines, interleukins are not stored within cells but are instead secreted rapidly, and briefly, in response to a stimulus, such as an infectious agent.