What do hematopoietic growth factors do?

Hematopoietic growth factors are a family of regulatory molecules that play important roles in the growth, survival, and differentiation of blood progenitor cells, as well as in the functional activation of mature cells.

What are the major hematopoietic growth factors?

They include interleukin-3 (IL-3), granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF) and erythropoietin (EPO).

What are the factors affecting hematopoiesis?

These factors include; the recombinant forms of two myeloid hematopoietic growth factors, granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF); erythropoietin (EPO), the red cell factor; stem cell factor (SCF), an early-acting hematopoietic growth factor; and the …

Is hematopoietic growth factor a cytokine?

Epo, GM-CSF, and G-CSF belong to a family of hematopoietic cytokines that includes growth hormone, prolactin, and IL-2 through IL-7 (Bazan, 1989). These cytokines share a predicted tertiary structure and function by binding to specific cell surface receptors.

What does hematopoietic tissue do?

The hematopoietic and lymphoid tissues give rise to and house erythrocytes (red blood cells), leukocytes (white blood cells), and platelets. The hematopoietic tissues arise from hematopoietic stem cells (HSCs) (Fig. 19.1), and include bone marrow, peripheral blood, and certain lymphoid tissue.

Where are most hematopoietic factors synthesized?

T lymphocytes, monocytes/macrophages, fibroblasts, and endothelial cells are the important cellular sources of most hematopoietic growth factors. Erythropoietin (EPO) is produced primarily by the adult kidney, and thrombopoietin (TPO) is produced in the liver and kidney.

What are the substances that control hematopoiesis?

Hematopoiesis Regulators

• Erythropoietin. Erythropoietin (EPO) regulates the process of erythropoiesis.
• Thrombopoietin.
• Stem Cell Factor.
• Interleukin 3 (IL-3), Interleukin 5 (IL-5) and Granulocyte Macrophage Colony Stimulating Factor (GM-CSF)
• Further Reading.

Which factor is responsible for normal hematopoiesis?

Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein cytokine that stimulates the growth, differentiation and activity of myeloid cells.

What are hematopoietic vitamins?

Several vitamins play important roles in hematopoietic system. Vitamin B12, C and folic acid are associated with DNA synthesis of erythroid nucleus, the deficiency of which causes the megaloblastic anemia. Some megaloblatic anemia and sideroblastic anemia might response to vitamin B1 and B6, respectively.

Where does Haematopoiesis take place?

bone marrow
In humans, hematopoiesis begins in the yolk sac and transitions into the liver temporarily before finally establishing definitive hematopoiesis in the bone marrow and thymus.